If you take two Benadryl how long does it take to wear off?


Best answer:
Benadryl is suppose to have a half life of 1 - 4 hours which keeps it in your system for up to about 8 hours.

From my experience, one Benadryl will keep me drowsy for 12 - 18 hours! Others can take it with no ill effects. It is one of those your mileage may vary type of drugs.
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